Innovative RF Filler Injection System

Introduction of Cellina

• What i s RF Filler ?
  - It is combined technology of Radiofrequency wave and Filler injections in one platform, which is an innovative minimally invasive technique for facial rejuvenation.
• Why RF Filler ?
  - INNOfill is essentially for facial rejuvenation and for the treatment of scars, stretch marks, and wrinkles combinedly working by RF thermal energy and hyaluronic acid filler.
• How does it work ?
  - Monopolar RF treatment has been demonstrated to induce a wound healing response with increased collagen expression and dermal remodeling results in gradual improvement over several months and can be long-lasting, while fillers often result in immediate clinical improvements that are usually temporary.
  Therefore, a filling/lifting/smoothing effect can be obtained, concerning the effects of aging, and a therapeutic effect occurs on acne scars and striae as well as most of facial rejuvenation.

General Parameter of INNOfill

Basic theory of RF Filler...

INNOfill consists mainly of following two effective performances.

• Monopolar RF mode
  - A conducted RF needle, specially formulated to apply radiofrequency is injected into skin and forms 'autologous containment capsule' in order to hold filler longer than ever since the bio-degradation goes slowly. And, Monopolar RF treatment stimulates dermis and helps re-modeling collagen immediately and gradually in long-term.
• Filler Injection
  - Soft-tissue filler augmentation is a treatment modality widely used for aesthetic improvement of deep facial lines and wrinkles. However, it is not well accepted for the patients who want longer filler duration.
• RF Filler
  - Soft-tissue augmentation and monopolar RF treatment have the potential to restore tissue volume and improve facial laxity.

Description

• 'A'
  - RF filler is for performing both RF emission and filler injection at same time.
  - RF only is for performing RF emission only using dedicated needle.
• 'B'
  - RF frequency will be selected either 1MHz or,
  - 2MHz depending on procedures.
• 'C'
  - It indicates the status of power and activation of procedures.
• 'D'
  - Control button for adjusting each parameters and values by push.
• 'E'
  - It shows time that is running currently.
• 'F'
  - It controls power level from 1 to 9 levels.

How to set INNOfill

How does INNOfill works

• Injecting RF needle into skin using linear retrograde technique with circular movement.
• Applying RF energy from the end of needle.
  - Formation of 'autologous containment capsule'
  - Re-modeling collagen
• To retrogress needle slowly inserting filler with one of following injection technique according to target.
  -. Linear / Serial puncture / Cross-hatching / Fan
  - Soft-tissue augmentation
• By using these two procedures, a filling/lifting/smoothing effect is therefore obtained, concerning the effects of aging, and a therapeutic effect occurs on acne scars and striae.

Advantages of INNOfill

• Lifting by RF energy and Volume-up by filler can be done in one platform.
• Long lasting efficacy thanks to RF + Filler technique.
• Non-invasive procedure thus the lesser down-time.
• A minimal side-effect by using well known accepted filler procedure.
• Available customized procedure depend on area to be treated.
• Expected lifting efficacy additionally by using RF + Filler mode.
• Reduction of usage of filler because of 'Autologous Containment Capsule'nearly 30%.

Result

Before Treatment (Day 0)	Day 8
Week 4	Week 8
Week 12

WSRS – Wrinkle Severity Rating Scale

Grade 1	Grade 2
Grade 3	Grade 4
Grade 5

• Grade 1 (absent):
  - no visible nasolabial fold; continuous skin line
• Grade 2 (mild):
  - shallow but visible nasolabial fold with a slight indentation; minor facial feature; implant is expected to produce a slight improvement in appearance
• Grade 3 (moderate):
  - moderately deep nasolabial fold; clear facial feature visible at normal appearance but not when stretched; excellent correction is expected from injectable implant
• Grade 4 (severe):
  - very long and deep nasolabial fold; prominent facial feature; < 2 mm visible fold when stretched; significant improvement is expected from injectable implant
• Grade 5 (extreme):
  - extremely deep and long nasolabial fold, detrimental to facial appearance;2~4mm visivle V-shaped fold when stretched; unlikely to have satisfactory correction with injectable alone

Clinical result of INNOfill

• Objective:
  - This clinical test is to verify a continuity and a visible volume up of filler stimulated by RF emission Conclusion: Monitoring result in 3 months, it is apparently observed a continuity of volume-up through RF filler treatments compared to the treatment done by only filler procedure.
• Implication:
  - Comparing to WSRS based on resting phase, it is scored delta value before and after of filler trt. (reviewer n=8) : deviation = SE (delta) Marked * only on p-value < 0.05
• Methods:
  - RF parameter: frequency-medium, mode-manual, power-15 watt Injected filler 0.5ml (Glytone 3) into nasolabial fold 4 times and forehead fold 2 times On the view of observer, RF Filler injected on left side and only filler on right side n= 3 Macrography on before and after of filler treatment  completion of test with 3 months monitoring

Comparison INNOfill and Spherofill